منابع مشابه
The Arabidopsis epitranscriptome.
The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention. mRNA methylation is required for normal Arabidopsis development and the first methylation maps revea...
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RNA modifications are indispensable for the translation machinery to provide accurate and efficient protein synthesis. Whereas the importance of transfer RNA (tRNA) and ribosomal RNA (rRNA) modifications has been well described and is unquestioned for decades, the significance of internal messenger RNA (mRNA) modifications has only recently been revealed. Novel experimental methods have enabled...
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RNA is decorated by various chemical modifications that affect the stability and localization of this fragilemolecule. These diverse, highly conserved, covalent modifications also help RNA perform its crucial roles in the cell. Over 100 RNAmodifications have been identified, primarily in noncoding RNAs (e.g., tRNA and rRNA). Less is known about the chemical modification of mRNA, although there ...
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Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts. Can new biological principles associated with this diversity of RNA modifications, particularly in mRNAs and long non-codin...
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Recent disgracing reports are warning the scientific communities to think more about the solutions to win the battle against predatory journals and publishers. Current integrity and accuracy in science is a result of decades of honest works and publications which are an asset, now everyone as stakeholders of science should feel the responsibility to sustain its high privileged level. The ethica...
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ژورنال
عنوان ژورنال: Science
سال: 2014
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aaa1807